Promethazine Symptoms and symptoms of overdosage with promethazine HCI range from mild depression in the central nervous technique and cardiovascular procedure to profound hypotension, respiratory despair, unconsciousness, and unexpected Dying.
Administer promethazine HCl and codeine phosphate oral solution by the oral route only. Normally use an precise milliliter measuring system when administering promethazine HCl and codeine phosphate oral Remedy to make certain the dose is measured and administered properly.
It is actually freely soluble in h2o and Liquor. Phenylephrine hydrochloride is matter to oxidation and must be protected against light-weight and air. It's a molecular body weight of 203.67, a molecular system of C9H13NO2 • HCl, and the next structural system:
They the two have the identical dose of Lively elements promethazine hydrochloride/codeine phosphate 6.25mg-10mg/5mL syrup.
Addiction, Abuse, and Misuse Promethazine HCl and codeine phosphate oral solution exposes people and various people on the pitfalls of opioid addiction, abuse, and misuse, which can result in overdose and Dying. Reserve promethazine HCl and codeine phosphate oral Resolution for use in adult people for whom the many benefits of cough suppression are predicted to outweigh the pitfalls, and in whom an enough assessment of your etiology on the cough continues to be built. Assess each affected individual’s threat just before prescribing promethazine HCl and codeine phosphate oral Option, prescribe promethazine HCl and codeine phosphate oral Remedy for your shortest period that's in line with particular person client therapy ambitions, monitor all sufferers regularly for the development of addition or abuse, and refill only immediately after reevaluation of the necessity for continued remedy. [see Warnings and Safety measures (five.one)] Existence-Threatening Respiratory Melancholy Major, existence-threatening, or deadly respiratory melancholy may perhaps happen with use of promethazine HCl and codeine phosphate oral Remedy. Watch for respiratory despair, especially in the course of initiation of promethazine HCl and codeine phosphate oral Resolution therapy or when Utilized in clients at bigger hazard [see Warnings and Precautions (five.two)]. Accidental Ingestion Accidental ingestion of even 1 dose of promethazine HCl and codeine phosphate oral solution, In particular by little ones, may result in a lethal overdose of codeine [see Warnings and Safety measures (5.2)]. Ultra-Rapid Metabolism of Codeine as well as other Danger Elements for all times-Threatening Respiratory Despair in Small children Lifetime-threatening respiratory depression and Loss of life have happened in little ones who gained codeine. The vast majority of described situations occurred following tonsillectomy and/or adenoidectomy, and a lot of of the kids had proof of getting an extremely-speedy metabolizer of codeine as a result of a CYP2D6 polymorphism [see Warnings and Safety measures (5.three)]. Promethazine HCl and codeine phosphate oral Option is contraindicated in youngsters younger than 12 years of age As well as in kids youthful than 18 many years of age next tonsillectomy and/or adenoidectomy [see Contraindications (4)]. Keep away from the usage of promethazine HCl and codeine phosphate oral Remedy in adolescents 12 to 18 decades of age who have other chance aspects that could maximize their sensitivity to the respiratory here depressant effects of codeine. Promethazine and Respiratory Depression in Children Postmarketing scenarios of respiratory depression, which includes fatalities are already documented with utilization of promethazine in pediatric sufferers.
Usually utilized orally, Akorn Cough Syrup dosages fluctuate in accordance with the product or service’s formulation and age. To prevent any adverse effects, it’s vital to adhere for the dosage tips created by a healthcare company or within the container.
WARNING: Retain this and all medications out in the attain of kids. In case of accidental overdose, seek out Experienced guidance or Make contact with a poison Regulate Centre promptly.
When offered concomitantly with promethazine, the dose of barbiturates should be reduced by not less than a person-50 percent, as well as the dose of narcotics ought to be reduced by just one-quarter to 1-half. Dosage need to be individualized. Extreme quantities of promethazine HCl relative into a narcotic may produce restlessness and motor hyperactivity while in the affected person with agony; these indicators generally vanish with sufficient Charge of the pain.
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This mixture is suitable for many respiratory difficulties because it successfully relieves coughs introduced on by colds, the flu, or allergic reactions.
Phenylephrine ought to be applied with caution in individuals with cardiovascular disease, notably hypertension.
If this SPL incorporates inactivated NDCs stated through the FDA initiated compliance action, they will be specified therefore.
Sedating prescription drugs may possibly lead to confusion and about-sedation inside the elderly; aged individuals generally should be started on reduced doses of promethazine hydrochloride and phenylephrine hydrochloride syrup and observed carefully.